“Thrombosis is the most feared complication of cardiovascular diseases and a main cause of death worldwide, making it a major health-care challenge. Platelets and the coagulation cascade are effectively targeted by antithrombotic approaches, which carry an inherent risk of
bleeding. Moreover, antithrombotics cannot completely prevent thrombotic events, implicating
a therapeutic gap due to a third, not yet adequately addressed mechanism, namely inflammation.”

“Thrombosis and inflammation are separate physiological processes yet an intense interdependence between these mechanisms has been recognized over the past decade.
Physiologically, inflammation-dependent activation of the coagulation system is part of the host response to pathogens, aiming to limit their systemic spread in the bloodstream. This response is achieved through an interplay between innate immune cells and platelets, triggering the activation of the coagulation system in a process termed immunothrombosis”

Stark K, Massberg S. Interplay between inflammation and thrombosis in cardiovascular pathology. Nat Rev Cardiol. 2021 Sep;18(9):666-682 Free Full Text