“Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), affects ~10 million people worldwide every year, representing the third most
common cardiovascular disease globally. The 30-day case fatality rate after VTE diagnosis is 10.6%, with about 30% to 50% of survivors developing long-term complications that increase
the burden of this disease.”

“This MR study provides new genetic evidence for the relationship between IMIDs and VTE risk. We found the existence of a causal association between UC and VTE/DVT risk, but no evidence for causal associations with other IMIDs, including CD, RA, SLE, and PSO. Our findings highlight the importance of active intervention and monitoring to mitigate VTE risk in patients with IBD, especially those presenting with ulcerative colitis. Future longitudinal clinical studies and experimental analyses are needed to confirm our findings.”

Lv X, et al . Immune-mediated inflammatory diseases and risk of venous thromboembolism: A Mendelian randomization study. Front Immunol. 2022 Dec 13;13:1042751. Free Full Text