“Crohn’s Disease is an inflammatory bowel disease with a multifactorial pathophysiology. Genetic, immune, gut microbiota, and other environmental factors play a role in the occurrence and maintenance of bowel inflammation. Unfortunately, despite the development of new drugs, about half of all CD patients will need surgery during their disease course.”

“A defect in innate immunity has been described in CD patients, reflected by a decreased accumulation of neutrophils and interleukin 8 in intestinal mucosa and the skin. Intrinsic properties in terms of transepithelial migration and impaired cellular signalling of neutrophils seem to be changed. This defect in innate immunity could have an impact on the clearance of translocated bacteria, leading to higher inflammatory response.”

de Buck van O et al . Postoperative Inflammatory Response in Crohn’s Patients: A Comparative Study. J Crohns Colitis. 2015 Dec;9(12):1127-31