“Extubation failure, defined as the inability to sustain spontaneous breathing after removal of the artificial airway and need for reintubation within 24–72 h or up to 7 days, is associated with high morbidity and mortality, as well as long term disability. Many studies have attempted to identify risk factors for extubation failure in order to prevent it. Nevertheless, the incidence of extubation failure in intensive care units (ICUs) remains quite high in the literature, between 10% within 48 h and 15% within 7 days.”

Anticipate the cause of extubation failure before extubation
“The FREE-REA study identified risk factors for air-way failure vs weaning failure among cases of extubation failure in a large multicenter, prospective cohort of extubated medical and surgical critically ill patients. Potentially actionable risk factors were identified: absence of strong cough associated with both airway failure and weaning failure, copious secretions associated with airway failure and Sequential Organ Failure Assessment (SOFA) score ≥ 8 associated with weaning failure.”

De Jong, Audrey et al. “How to optimize extubation?.” Intensive care medicine vol. 49,3 (2023): 337-340. Full Text for Emory Users