“Chronic intestinal failure (CIF) is a rare but feared severe complication of
Crohn’s disease, with 60% of patients permanently dependent on parenteral nutrition.
This review aims to summarize the knowledge available in the current literature
describing recent advances in the management and treatment of adult patients with
CIF, with emphasis on patients with Crohn’s disease. Moreover, it aims to further
understanding of modern approaches to CIF complications such as catheter-related
bloodstream infections and intestinal failure-associated liver disease.”

“While considerable advances have been made in recent years with regard to the
understanding and management of CIF and its various related complications, it
remains a challenging disorder. Home-based PN has brought distinct benefits, partic-
ularly in terms of higher survival rates and improved patient quality of life.
Nevertheless, more than half of patients with CIF require PN on a permanent basis.
While the traditional mainstays of pharmacological management are antimotility and
antisecretory drugs, new hormonally acting drugs that stimulate intestinal adaptation,
such as teduglutide, have had encouraging results, adding a new dimension to CIF
therapy.”

Aksan, Aysegül et al. “Chronic intestinal failure and short bowel syndrome in Crohn’s disease.” World journal of gastroenterology vol. 27,24 (2021): 3440-3465. Free Full Text