Surgical Grand Rounds: Articles of interest

Dr. Nathan Klingensmith referenced the following citations during his presentation, “The Microbiome in Surgery: Friend or Foe?” on November 22, 2019.


Fay KT, Klingensmith NJ, Chen CW, Zhang W, Sun Y, Morrow KN, Liang Z, Burd EM, Ford ML, Coopersmith CM. The gut microbiome alters immunophenotype and survival from sepsis. FASEB J. 2019 Oct;33(10):11258-11269.

Sender R, Fuchs S, Milo R, et al. Revised Estimates for the Number of Human and Bacteria Cells in the Body. PLoS Biol. 2016 Aug 19;14(8):e1002533.

Lloyd-Price J, Abu-Ali G, Huttenhower C. The healthy human microbiome. Genome Med. 2016 Apr 27;8(1):51.

Vrieze A, et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology. 2012 Oct;143(4) :913-6.e7.

Fujimura KE, Sitarik AR, Havstad S, et al. Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation. Nat Med. 2016 Oct;22(10) :1187-1191.

Nagata N, Tohya M, Fukuda S, et al. Effects of bowel preparation on the human gut microbiome and metabolome. Sci Rep. 2019 Mar 11;9(1):4042.

Theriot CM, Young VB. Interactions Between the Gastrointestinal Microbiome and Clostridium difficile. Annu Rev Microbiol. 2015;69:445-61.

Halfvarson J, Brislawn CJ, Lamendella R, et al. Dynamics of the human gut microbiome in inflammatory bowel disease. Nat Microbiol. 2017 Feb 13;2:17004.

Scarborough JE, Mantyh CR, Sun Z, Migaly J. Combined Mechanical and Oral Antibiotic Bowel Preparation Reduces Incisional Surgical Site Infection and Anastomotic Leak Rates After Elective Colorectal Resection: An Analysis of Colectomy-Targeted ACS NSQIP. Ann Surg. 2015 Aug;262(2):331-7.

COHN I Jr, RIVES JD. Antibiotic protection of colon anastomoses.Ann Surg. 1955 May; 141(5):707-17.

Schardey HM, Joosten U, Finke U, et al. The prevention of anastomotic leakage after total gastrectomy with local decontamination. A prospective, randomized, double-blind, placebo-controlled multicenter trial. Ann Surg. 1997 Feb;225(2):172-80.

Babrowski T, Holbrook C, Moss J, et al. Pseudomonas aeruginosa virulence expression is directly activated by morphine and is capable of causing lethal gut-derived sepsis in mice during chronic morphine administration. Ann Surg. 2012 Feb;255(2):386-93.

Vétizou M, Pitt JM, Daillère R, Lepage P, et al. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science. 2015 Nov 27;350(6264):1079-84.

Pushalkar S, Hundeyin M, Daley D, et al. The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression. Cancer Discov. 2018 Apr;8(4):403-416.

Aykut B, Pushalkar S, Chen R, et al. The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL. Nature. 2019 Oct;574(7777):264-267.

Yoseph BP, Klingensmith NJ, Liang Z, Breed ER, Burd EM, Mittal R, Dominguez JA, Petrie B, Ford ML, Coopersmith CM. Mechanisms of Intestinal Barrier Dysfunction in Sepsis.Shock. 2016 Jul;46(1):52-9.

Fay KT, Ford ML, Coopersmith CM, et al. The intestinal microenvironment in sepsis.Biochim Biophys Acta Mol Basis Dis. 2017 Oct;1863(10 Pt B):2574-2583.

Cheng YW, Phelps E, Ganapini V,  et al. Fecal microbiota transplantation for the treatment of recurrent and severe Clostridium difficile infection in solid organ transplant recipients: A multicenter experience. Am J Transplant. 2019 Feb;19(2):501-511.

Koskenvuo L, Lehtonen T, Koskensalo S, et al. Mechanical and oral antibiotic bowel preparation versus no bowel preparation for elective colectomy (MOBILE): a multicentre, randomised, parallel, single-blinded trial. Lancet. 2019 Sep 7;394(10201):840-848.

Yeo IB, et al. A discussion on intestinal antiseptics. The British Medical Journal. 1899 Nov 4:1250-7.

Engel DR, Koscielny A, Wehner S, et al.T helper type 1 memory cells disseminate postoperative ileus over the entire intestinal tract. Nat Med. 2010 Dec;16(12):1407-13.


More on Emory’s Surgical Grand Rounds.

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