Essential articles: Surgical oncology

Abdominal (Malignant):

Al-Batran SE, et al. Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial Lancet. 2019 May 11;393(10184):1948-1957. doi: 10.1016/S0140-6736(18)32557-1.   

Shapiro J, et al. Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial Lancet Oncol. 2015 Sep;16(9):1090-1098. doi: 10.1016/S1470-2045(15)00040-6.   

Degiuli M, et al. Randomized clinical trial comparing survival after D1 or D2 gastrectomy for gastric cancer Br J Surg. 2014 Jan;101(2):23-31. doi: 10.1002/bjs.9345. 

Bang YJ, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial Lancet. 2010 Aug 28;376(9742):687-97. doi: 10.1016/S0140-6736(10)61121-X.   

Cunningham D, et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer N Engl J Med. 2006 Jul 6;355(1):11-20. doi: 10.1056/NEJMoa055531. 

Macdonald JS, et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction N Engl J Med. 2001 Sep 6;345(10):725-30. doi: 10.1056/NEJMoa010187. 


Ajani JA, et al. Esophageal and Esophagogastric Junction Cancers, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology J Natl Compr Canc Netw. 2019 Jul 1;17(7):855-883. doi: 10.6004/jnccn.2019.0033. 

van Hagen P, et al. Preoperative chemoradiotherapy for esophageal or junctional cancer N Engl J Med. 2012 May 31;366(22):2074-84. doi: 10.1056/NEJMoa1112088. 


Fernandez FG, et al. Utility of mediastinoscopy in clinical stage I lung cancers at risk for occult mediastinal nodal metastases J Thorac Cardiovasc Surg. 2015 Jan;149(1):35-41, 42.e1. doi: 10.1016/j.jtcvs.2014.08.075. Epub 2014 Sep 17. 

Albain KS, et al. Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III randomised controlled trial Lancet. 2009 Aug 1;374(9687):379-86. doi: 10.1016/S0140-6736(09)60737-6. Epub 2009 Jul 24. 

Ettinger DS, et al. NCCN Guidelines Insights: Non-Small Cell Lung Cancer, Version 1.2020 J Natl Compr Canc Netw. 2019 Dec;17(12):1464-1472. doi: 10.6004/jnccn.2019.0059. 

Antonia SJ, et al. Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC N Engl J Med. 2018 Dec 13;379(24):2342-2350. doi: 10.1056/NEJMoa1809697.  

Boffa DJ, et al. Minimally Invasive Lung Cancer Surgery Performed by Thoracic Surgeons as Effective as Thoracotomy J Clin Oncol. 2018 Aug 10;36(23):2378-2385. doi: 10.1200/JCO.2018.77.8977.  

Shen KR, et al. The American Association for Thoracic Surgery consensus guidelines for the management of empyema J Thorac Cardiovasc Surg. 2017 Jun;153(6):e129-e146. doi: 10.1016/j.jtcvs.2017.01.030.  

Fernandez FG, et al. The Society of Thoracic Surgeons Lung Cancer Resection Risk Model: Higher Quality Data and Superior Outcomes Ann Thorac Surg. 2016 Aug;102(2):370-7. doi: 10.1016/j.athoracsur.2016.02.098.  

Khullar OV, et al. Survival After Sublobar Resection versus Lobectomy for Clinical Stage IA Lung Cancer: An Analysis from the National Cancer Data Base J Thorac Oncol. 2015 Nov;10(11):1625-33. doi: 10.1097/JTO.0000000000000664. 

Wallis A, et al. The diagnosis and management of interstitial lung diseases BMJ. 2015 May 7;350:h2072. doi: 10.1136/bmj.h2072. 

Pardolesi A, et al. Robot-assisted lung anatomic segmentectomy: technical aspects Thorac Surg Clin. 2014 May;24(2):163-8, vi. doi: 10.1016/j.thorsurg.2014.02.008. 

National Lung Screening Trial Research Team. Reduced lung-cancer mortality with low-dose computed tomographic screening N Engl J Med. 2011 Aug 4;365(5):395-409. doi: 10.1056/NEJMoa1102873.  

Pignon JP, et al. Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE Collaborative Group J Clin Oncol. 2008 Jul 20;26(21):3552-9. doi: 10.1200/JCO.2007.13.9030.  

Fishman A, et al. A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema N Engl J Med. 2003 May 22;348(21):2059-73. doi: 10.1056/NEJMoa030287.  

Ginsberg RJ, et al. Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group Ann Thorac Surg. 1995 Sep;60(3):615-22; discussion 622-3. doi: 10.1016/0003-4975(95)00537-u. 


Andtbacka RH, et al. Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma J Clin Oncol. 2015 Sep 1;33(25):2780-8. doi: 10.1200/JCO.2014.58.3377.  

Angeles CV, et al. The Landmark Series: Randomized Trials Examining Surgical Margins for Cutaneous Melanoma Ann Surg Oncol. 2020 Jan;27(1):3-12. doi: 10.1245/s10434-019-07866-y.  

Beasley GM, et al. The Landmark Series: Regional Therapy of Recurrent Cutaneous Melanoma Ann Surg Oncol. 2020 Jan;27(1):35-42. doi: 10.1245/s10434-019-07760-7.  

Bello DM, et al. The Landmark Series: MSLT-1, MSLT-2 and DeCOG (Management of Lymph Nodes) Ann Surg Oncol. 2020 Jan;27(1):15-21. doi: 10.1245/s10434-019-07830-w.  

Delman KA, et al. Completion Node Dissection After Sentinel Node Biopsy in Melanoma JAMA Surg. 2018 Nov 1;153(11):1045-1046. doi: 10.1001/jamasurg.2018.1516. 

Faries MB, et al. Completion Dissection or Observation for Sentinel-Node Metastasis in Melanoma N Engl J Med. 2017 Jun 8;376(23):2211-2222. doi: 10.1056/NEJMoa1613210. 

Lee AY, et al. The Landmark Series: Non-melanoma Skin Cancers Ann Surg Oncol. 2020 Jan;27(1):22-27. doi: 10.1245/s10434-019-07831-9.  

Leiter U, et al. Final Analysis of DeCOG-SLT Trial: No Survival Benefit for Complete Lymph Node Dissection in Patients With Melanoma With Positive Sentinel Node J Clin Oncol. 2019 Nov 10;37(32):3000-3008. doi: 10.1200/JCO.18.02306.  

Morton DL, et al. Final trial report of sentinel-node biopsy versus nodal observation in melanoma N Engl J Med. 2014 Feb 13;370(7):599-609. doi: 10.1056/NEJMoa1310460. 

Wong SL, et al. Sentinel Lymph Node Biopsy and Management of Regional Lymph Nodes in Melanoma: American Society of Clinical Oncology and Society of Surgical Oncology Clinical Practice Guideline Update J Clin Oncol. 2018 Feb 1;36(4):399-413. doi: 10.1200/JCO.2017.75.7724.  


Casali PG, et al. Gastrointestinal stromal tumours: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up Ann Oncol. 2018 Oct 1;29(Suppl 4):iv68-iv78. doi: 10.1093/annonc/mdy095. 

Casali PG, et al. Soft tissue and visceral sarcomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up Ann Oncol. 2018 Oct 1;29(Suppl 4):iv51-iv67. doi: 10.1093/annonc/mdy096. 

Chudgar NP, et al. Pulmonary metastasectomy with therapeutic intent for soft-tissue sarcoma J Thorac Cardiovasc Surg. 2017 Jul;154(1):319-330.e1. doi: 10.1016/j.jtcvs.2017.02.061.  

Dematteo RP, et al. Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial Lancet. 2009 Mar 28;373(9669):1097-104. doi: 10.1016/S0140-6736(09)60500-6.  

Haas RL, et al. Preoperative radiotherapy in soft tissue sarcoma: from general guidelines to personalized medicine Chin Clin Oncol. 2018 Aug;7(4):41. doi: 10.21037/cco.2018.05.02.   

Kasper B, et al. An update on the management of sporadic desmoid-type fibromatosis: a European Consensus Initiative between Sarcoma PAtients EuroNet (SPAEN) and European Organization for Research and Treatment of Cancer (EORTC)/Soft Tissue and Bone Sarcoma Group (STBSG) Ann Oncol. 2017 Oct 1;28(10):2399-2408. doi: 10.1093/annonc/mdx323. 

Roland CL, et al. The Landmark Series: Multimodality Treatment of Extremity Sarcoma. Ann Surg Oncol. 2020 Oct;27(10):3672-3682.

Wang J, et al. Surgical management of retroperitoneal sarcoma and opportunities for global collaboration Chin Clin Oncol. 2018 Aug;7(4):39. doi: 10.21037/cco.2018.07.05. 

Desmoid & Mesothelioma

Fiore M, et al. The Landmark Series: Desmoid. Ann Surg Oncol. 2021 Mar;28(3): 1682-1689.

Kantor T, Wakeam E. Landmark Trials in the Surgical Management of Mesothelioma. Ann Surg Oncol. 2021 Apr; 28(4):2037-2047.

Small Bowel Cancers

Tran CG, et al. The Landmark Series: Management of Small Bowel Neuroendocrine Tumors. Ann Surg Oncol. 2021 May;28(5):2741-2751.

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