“In this retrospective study, all patients who had gastrectomy for cancer between 2007 and 2017 in French tertiary centers were included. The outcome was a diagnosis of GLP based on pathological review of the surgical specimen. The diagnostic score was created by using variables that were most frequently associated with GLP using penalized logistic
regression on multiply imputed datasets. We used discrimination measures to assess the performances of the score. Internal validation was performed using bootstrapping methods to correct for over-optimism.”

“We have constructed and validated the first score to diagnose GLP with high sensitivity and specificity (Saint Louis linitis score). This one is composed of six parameters easily applicable in clinical practice and allows to determine a homogeneous group of patients in a pathology where there is no consensual definition. The use of this score may help to improve the therapeutic management of this subtype of GA, in particular the interest of preoperative chemotherapy and the extent of gastric resection if planned.”

Vivier-Chicoteau J, et al Development and internal validation of a diagnostic score for gastric linitis plastica. Gastric Cancer. 2020 Jul;23(4):639-647. Full Text for Emory Users