“Among patients undergoing lumpectomy and Sentinel Lymph Node Biopsy with multimodal analgesia, the risk of hematoma in the 30-day postoperative period, including hematoma requiring reoperation and in-office aspiration or drainage, was low overall and not statistically significantly higher despite increased use of intraoperative ketorolac and implementtion of a standard discharge regimen of NSAIDs in lieu of opioids.”

“As the reduction of opioid use remains a public health priority, nonsteroidal anti-inflammatory drugs (NSAIDs) are increasingly used for perioperative and postdischarge pain control in patients undergoing ambulatory breast surgery. Data suggest that multimodal analgesia—including intravenous and oral NSAIDs, both key components of enhanced recovery after surgery protocols—is associated with reduced perioperative opioid requirement without compromising pain control or patient satisfaction.”

Pawloski KR, et al Postdischarge Nonsteroidal Anti-Inflammatory Drugs Are not Associated with Risk of Hematoma after Lumpectomy and Sentinel Lymph Node Biopsy with Multimodal Analgesia. Ann Surg Oncol. 2021 Oct;28(10):5507-5512. doi: 10.1245/s10434-021-10446-8. Epub 2021 Jul 10