Selection of pancreaticojejunostomy technique after pancreaticoduodenectomy: duct-to-mucosa anastomosis is not better than invagination anastomosis

“Pancreaticoduodenectomy (PD) is a complex, high-risk standard surgical procedure that is indicated primarily for periampullary diseases. Central to the entire discipline of PD are postoperative mortality and morbidity. Although operative mortality in patients undergoing PD has decreased, the incidence of postoperative morbidity remains high at 40% to 50%. Postoperative pancreatic fistula (POPF) is the most common complication, with rates ranging from 5% to 30% in previous studies. Many methods have been described to decrease the risk of POPF, including the use of medications (prophylactic octreotide, sealants), prophylactic pancreatic stenting, and improvements in pancreatic reconstruction techniques. The most commonly used pancreatic reconstruction techniques are pancreaticogastrostomy (PG) and pancreaticojejunostomy (PJ).”

Continue reading

Occlusion of the Pancreatic Duct Versus Pancreaticojejunostomy

“Pancreatic fistulas and pancreatitis may develop in the pancreatic remnant and may lead to hemorrhage, sepsis, and subsequent death. Procedures to avoid pancreaticojejunostomy were described, including total pancreatectomy. None of these has so far proven to diminish morbidity significantly. Another technique investigated is obliteration closure of the pancreatic duct with a chemical substance, thus avoiding a pancreaticojejunostomy. This method was proposed by Gebhardt et al. They studied the effect of occlusion of the pancreatic duct system with Ethibloc, an alcoholic prolamine, in animal experiments. The pancreatic duct may also be occluded with a fibrin glue solution, Tissucol, which was found to have a more protective effect on beta cell function than the other solutions used.”

Continue reading