Japanese Gastric Cancer Treatment Guidelines 2021

Posted on September 8, 2025 by John

“The sixth edition of the Japanese Gastric Cancer Treatment Guidelines was completed in July 2021, incorporating new evidence that emerged after publication of the previous edition. It consists of a text-based “Treatments” part and a “Clinical Questions” part including recommendations and explanations for clinical questions. The treatments parts include a comprehensive description regarding surgery, endoscopic resection and chemotherapy for gastric cancer. The clinical question part is based on the literature search and evaluation by an independent systematic review team.”

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Validation of a diagnostic score for gastriclinitis plastica

Posted on January 25, 2024 by John

“In this retrospective study, all patients who had gastrectomy for cancer between 2007 and 2017 in French tertiary centers were included. The outcome was a diagnosis of GLP based on pathological review of the surgical specimen. The diagnostic score was created by using variables that were most frequently associated with GLP using penalized logistic
regression on multiply imputed datasets. We used discrimination measures to assess the performances of the score. Internal validation was performed using bootstrapping methods to correct for over-optimism.”

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Is Linitis Plastica a Contraindication for Surgical Resection?

Posted on January 25, 2024 by John

“The diagnosis of LP carries significant controversy regarding its surgical management.
Lymph node involvement is almost always present at the time of diagnosis, and due to its
diffuse nature, microscopic disease is often found at the resection margins. Peritoneal
dissemination is frequently encountered at the time of surgery or as the main site of
recurrence. As such, curative resection is possible in less than half of patients and early
recurrence is common, leading to a dismal median survival, ranging from 6 to 12 months,
and 5-year survival between 8 and 13 %.”

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Clinicopathologic features and survival outcomes of patients with Linitis Plastica

Posted on January 25, 2024 by John

“Linitis plastica (LP) is a distinct phenotype of gastric cancer. Macroscopically, it is characterized as a thickened stomach, with prominent diffusion of the tumor into the submucosal and muscular layers; microscopically, it is often associated with signet ring cell features and diffuse and scirrhous (referring to the histologic characteristic of abundant stromal cells) histologic types.”