“Despite decades of descriptive research, the etiology and pathogenesis of AL remains unknown. Although there is compelling evidence that microbes are the primary drivers of the pathogenesis of anastomotic leak, few efforts have been aimed at understanding and controlling the microbes that may complicated anastomotic healing.”
“A microbial cause for anastomotic leak was first proposed over 60 years ago and has been confirmed in multiple studies. The main clinical evidence for a microbial cause of anastomotic leak is indirect and is based on clinical trials in which the use of oral non-absorbable antibiotics significantly reduce the incidence of anastomotic leak”



