Laparoscopic mesh versus suture repair of hiatus hernia

“Hiatus hernia contributes to the pathophysiology of gastroesophageal reflux disease (GERD). Mesh-augmentation of surgical repair might be associated with a reduced risk of recurrence and GERD. However, recurrence rates, mesh-associated complications and quality of life after mesh versus suture repair are debated. The aim of this meta-analysis was to determine HH recurrence following mesh-augmentation versus suture repair.”

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Perioperative considerations for patients with epilepsy

“Epilepsy is the most common serious neurological disorder, with a prevalence of 0.5–1% of the population. Anaesthetists are frequently faced with patients with epilepsy undergoing
emergency or elective surgery and patients suffering seizures and status epilepticus in the intensive care unit (ICU).”

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Liver Transplantation in Acute-on-chronic Liver Failure

“Liver transplantation (LT) has revolutionized the treatment of cirrhotic patients. However, access to transplant is limited as demand for organs exceeds availability. Current allocation gives the highest priority to patients with the highest mortality risk. Hence, several
patients awaiting LT may deteriorate while waiting for LT.”

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Enhanced Recovery and Perioperative Quality Initiative on Nutrition Screening and Therapy Within a Surgical Enhanced Recovery Pathway

“Perioperative malnutrition has proven to be challenging to define, diagnose, and treat. Despite these challenges, it is well known that sub-optimal nutritional status is a strong independent predictor of poor postoperative outcomes.”

“Malnourished surgical patients have significantly higher postoperative mortality, morbidity, length of stay (LOS), readmission rates, and increased hospital costs.It is estimated that 24%–65% of patients undergoing surgery are at nutrition risk. Additionally, recent prospective observational data indicate that undernourished patients or patients at risk of malnutrition are twice as likely to be readmitted within 30 days after elective colorectal surgery.”

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Immune-mediated inflammatory diseases and risk of venous thromboembolism:

“Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), affects ~10 million people worldwide every year, representing the third most
common cardiovascular disease globally. The 30-day case fatality rate after VTE diagnosis is 10.6%, with about 30% to 50% of survivors developing long-term complications that increase
the burden of this disease.”

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Inflammation and thrombosis in cardiovascular pathology

“Thrombosis is the most feared complication of cardiovascular diseases and a main cause of death worldwide, making it a major health-care challenge. Platelets and the coagulation cascade are effectively targeted by antithrombotic approaches, which carry an inherent risk of
bleeding. Moreover, antithrombotics cannot completely prevent thrombotic events, implicating
a therapeutic gap due to a third, not yet adequately addressed mechanism, namely inflammation.”

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Risk of postoperative deep vein thrombosis and pulmonary embolism in patients with inflammatory bowel disease

“An increased risk of DVT and PE in patients with IBD has been evident for the past 75 years. Most work in this area has not looked specifically at patients undergoing surgery. Patients with IBD frequently require surgical intervention, and an understanding of their risk of venous thromboembolism is therefore an important issue. This study aimed to examine rates of DVT and PE in patients with IBD undergoing surgery using data from the NSQIP.”

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