Author Archives: John

Risk factors for postoperative bleeding and early death in percutaneous endoscopic gastrostomy

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“Gastrostomy is a method of tube feeding for patients incapable of oral intake. Percutaneous endoscopic gastrostomy (PEG) is performed in many hospitals in Japan. However, reports of postoperative bleeding or early postoperative death after PEG are limited.
Compared with nasogastric tube feeding, gastrostomy feeding has a favorable outcome, decreases treatment failure, decreases the frequency of gastrointestinal bleeding, and leads to increased serum albumin levels. However, as PEG is an invasive procedure, adverse events such as bleeding, local infection, peritonitis, and pulmonary aspiration may occur, thus worsening patient prognosis. Aspiration pneumonia has long been recognized as the
most common cause of death after PEG. However, there are no recent large-scale studies investigating the association between postoperative adverse events and early postoperative death in PEG.”

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Respiratory Failure in Amyotrophic Lateral Sclerosis

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“Amyotrophic lateral sclerosis is a progressive neuromuscular disease characterized by both
lower motor neuron and upper motor neuron dysfunction. Although clinical presentations can vary, there is no cure for ALS, and the disease is universally terminal, with most patients dying of respiratory complications. Patients die, on average, within 3 to 5 years of diagnosis, unless they choose to undergo tracheostomy, in which case, they may live, on average, 2 additional years. Up to 95% of patients with ALS in the United States choose not to undergo tracheostomy; management of respiratory failure is therefore aimed at both prolonging survival as well as improving quality of life. Standard of care for patients with ALS includes treatment from multidisciplinary teams, but many patients do not have consistent access to a pulmonary physician who regularly sees patients with this disease.”

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Small bowel obstructions following the use of barbed suture

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“Barbed suture has been adopted across all surgical specialties. One of the infrequent complications seen with the use of barbed suture is small bowel obstructions (SBOs). In this study, we perform a review of the literature and the Manufacturer and User Facility Device Experience Database (MAUDE) to characterize SBOs after the use of barbed sutures
in a variety of operative procedures.”

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Abdominal fascia dehiscence: is there a connection to a special microbial spectrum?

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“Acute fascia dehiscence (FD) is a threatening complication occurring in 0.4–3.5% of cases after abdominal surgery. Prolonged hospital stay, increased mortality and increased rate of incisional hernias could be following consequences. Several risk factors are controversially discussed. Even though surgical infection is a known, indisputable risk factor, it is still not proven if a special spectrum of pathogens is responsible. In this study, we investigated if a specific spectrum of microbial pathogens is associated with FD.”

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Diagnosis of Anastomotic Leak

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“Anastomotic leaks after colorectal surgery is associated with increased morbidity and
mortality. Understanding the impact of anastomotic leaks and their risk factors can
help the surgeon avoid any modifiable pitfalls. The diagnosis of an anastomotic leak can
be elusive but can be discerned by the patient’s global clinical assessment, adjunctive
laboratory data and radiological assessment. The use of inflammatory markers such as
C-Reactive Protein and Procalcitonin have recently gained traction as harbingers for a
leak. A CT scan and/or a water soluble contrast study can further elucidate the location
and severity of a leak. Further intervention is then individualized on the spectrum of
simple observation with resolution or surgical intervention.”

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Classification, surgical management and outcomes of patients with gastrogastric fistula after Roux-En-Y gastric bypass

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“Gastrogastric fistula (GGF) was a well-described complication after nondivided Roux-en-Y gastric bypass (RYGB), with a documented rate of up to 50%. Gastric transection with isolation of the gastric pouch (divided RYGB) reduces but does not eliminate this complication, which still occurs with a reported incidence ranging from 0% to 6%. Weight regain, epigastric pain, and marginal ulcer (MU) are the most common symptoms. Some GGF can be managed conservatively or by endoscopic approach, but surgery remains the standard of care.”

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Decreasing Hospital Readmission in Ileostomy Patients

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“Nearly 30% of patients with newly formed ileostomies require hospital readmission from severe dehydration or associated complications. This contributes to significant morbidity and rising healthcare costs associated with this procedure. The aim of this study was to design and pilot a novel program to decrease readmissions in this patient population.”

“Implementation of a novel program reduced the 30-day readmission rate by 58% and cost of readmissions per patient by >80% in a high risk for readmission patient population with newly created ileostomies. Future efforts will expand this program to a greater number of patients, both institutionally and systemically, to reduce the readmission-rate and healthcare
costs for this high-risk patient population.”

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