A systematic review of the role of prophylactic ureteric stenting prior to colorectal resections

“There is a need for strategies to reduce the risk of ureteric injury, and to facilitate immediate recognition, during colorectal procedures. The preoperative placement of prophylactic ureteric stents or catheters has long been discussed as a technique that may assist colorectal surgeons in identifying and avoiding the ureters, and in recognising ureteric injury when it occurs.
Debate surrounds this topic, however, with no consensus on the precise benefit of prophylactic ureteric stents, and some concerns regarding potential stent-related complications. Whilst the European Association of Urology (EAU) guidelines state that ‘visual identification of the ureters and meticulous dissection in their vicinity are mandatory
to prevent ureteral trauma during abdominal and pelvic surgery’ (grade A recommendation), the use of ‘preoperative prophylactic stents’ are recommended only ‘in selected cases (based on risk factors and surgeon’s experience)’ (grade B). The American Society of Colon and Rectal Surgeons guidelines in surgery for diverticulitis state ‘ureteral stents are used at the discretion of the surgeon’ (grade 2C).

Table 4 Type of repair and outcomes of ureteric injuries

StudyInjuries (n)Stented and recognised intraoperativelyStented and recognised postoperativelyUnstented and recognised intraoperativelyUnstented and recognised postoperatively
Bothwell [41](open)4/5611/4—primary repair over stent1/4 (stent insertion had failed)—nephrostomy + stent1/4—stent inserted and repair performed1/4 re-exploration and ureteroureterostomy
Beraldo [32](laparoscopic)1/891/89—repair technique not specified
Boyan [34] (laparoscopic)None
Chahin [35]1/661/66 recognised day 2, managed by retrograde stent reinsertion
Chiu [8]2503/811,071Not evaluated
Coakley [3]333/51,125Not evaluated
Chong [29]None
Hassinger [38]Not evaluated
Kutiyanawala [44]5/251No stented patientsNo stented patients3/5—ureteric re-implant × 2 and ureteroureterostomy over stent in × 12/5Nephrostomy + JJ stent × 1 (prolonged recovery, fistula)Relaparotomy + removal of ligasure × 1
Kyzer [33]1/1181/1 repair technique not specified
Leff [19]4/1943/4OPEN intraoperative repair1/4—delayed presentation as ureteral-cutaneous fistulaNot evaluatedNot evaluated
Luks [39]2/2612/2 intraoperative repair, type unspecified
Merola [28]1/374None1 injury, recognised postoperatively—re-operation (repair not specified)NoneNone
Nam [27]None
Pathak [42]None
Palaniappa [45] 2012(Open arm)7/46691/7Ureteroneocystostomy1/7Nephrostomy3/7Ureteroneocystostomy × 1, ureteroureterostomy × 22/7Bilateral nephrostomies × 1Ureteroureterostomy × 1
Palaniappa [45]2012(Laparoscopic arm)7/10601/7 Ureteroureterostomy1/7 Ureteroneocystostomy2/7Ureteroneocystostomy × 1Ureteroureterostomy × 13/7Ureteroneocystostomy × 1Nephrostomy × 2
Pokala [30]0
Sahoo [40]0    
Senagore [36]0
Sheikh [43]Not reported
Speicher [31]Not reported
Tsujinaka [37]0

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Systematic review of preoperative, intraoperative and postoperative risk factors for colorectal anastomotic leaks

“Anastomotic leak (AL) represents a dreaded complication following colorectal surgery, with a prevalence of 1-19 per cent. There remains a lack of consensus regarding factors that may predispose to AL and the relative risks associated with them. The objective was to perform a systematic review of the literature, focusing on the role of preoperative, intraoperative and postoperative factors in the development of colorectal ALs.”

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Simultaneous resection of primary colorectal cancer and synchronous liver metastases

Kleive D, et al. Simultaneous Resection of Primary Colorectal Cancer and Synchronous Liver Metastases: Contemporary Practice, Evidence and Knowledge Gaps. Oncol Ther. 2021 Jun;9(1):111-120. Free full-text.

Key Summary Points

  • High-level evidence in simultaneous resection of colorectal cancer and colorectal liver metastasis remains scarce.
  • Simultaneous resections may be considered in patients with good performance status and limited liver tumour burden.
  • Simultaneous resections should be avoided when requiring major liver resection and major colorectal resection.
  • Treatment strategies should be made by a multidisciplinary team.
  • Simultaneous resections should be performed as part of a clinical trial.
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Surgical Management of Liver Metastases From Colorectal Cancer

“Surgical resection remains one of the major curative treatment options available to patients
with colorectal liver metastases. Surgery and chemotherapy form the backbone of the
treatment in patients with colorectal liver metastases. With more effective chemotherapy
regimens being available, the optimal timing and sequencing of treatments are important. A
multidisciplinary approach with the involvement of medical oncologists and surgical
oncologists from the beginning is crucial.”

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Colorectal liver metastases

“Colorectal cancer (CRC) represents a major worldwide health care burden, as the
second most common cancer diagnosed in women and third most common in men,
and accounting for 10% of all annually diagnosed cancers and cancer-related deaths
worldwide.
As result of improvements in detection through screening, better referral
pathways, centralisation of services, effective primary surgery, development of
systemic chemotherapy, biological agents, and understanding of tumour biology,
survival rates following diagnosis have improved.
Nevertheless, at least 25%-50% of patients with CRC develop colorectal liver
metastases (CRLM) during the course of their illness.”

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The utility of intraoperative perfusion assessment during resection of colorectal cancer

De Nardi P, et al. Intraoperative angiography with indocyanine green to assess anastomosis perfusion in patients undergoing laparoscopic colorectal resection: results of a multicenter randomized controlled trial. Surg Endosc. 2020 Jan;34(1):53-60.

Full-text for Emory users.

Results: After randomization, 12 patients were excluded. Accordingly, 240 patients were included in the analysis; 118 were in the study group, and 122 in the control group. ICG angiography showed insufficient perfusion of the colic stump, which led to extended bowel resection in 13 cases (11%). An anastomotic leak developed in 11 patients (9%) in the control group and in 6 patients (5%) in the study group (p = n.s.).

Conclusions: Intraoperative ICG fluorescent angiography can effectively assess vascularization of the colic stump and anastomosis in patients undergoing colorectal resection. This method led to further proximal bowel resection in 13 cases, however, there was no statistically significant reduction of anastomotic leak rate in the ICG arm.

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Iatrogenic ureteral injury in colorectal cancer surgery

Andersen P, et al. Iatrogenic ureteral injury in colorectal cancer surgery: a nationwide study comparing laparoscopic and open approaches. Surg Endosc. 2015 Jun;29(6): 1406-12.

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Results: A total of 18,474 patients had a resection for colorectal cancer. Eighty-two ureteral injuries were related to colorectal surgery. The rate of ureteral injuries in the entire cohort was 0.44 %, with 37 (0.59 %) injuries in the laparoscopic group (n = 6,291) and 45 (0.37 %) injuries in the open group (n = 12,183), (P = 0.03). No difference in ureteral injury was found in relation to surgical approach in colon cancer patients. In rectum cancer patients (n = 5,959), the laparoscopic approach was used in 1,899 patients, and 19 (1.00 %) had ureteral injuries, whereas 17 (0.42 %) of 4,060 patients who underwent an open resection had a ureteral injury. In multivariate analysis adjusted for age, gender, ASA score, BMI, tumor stage, preoperative chemo-radiation, calendar year, and specialty of the surgeon, the laparoscopic approach was associated with an increased risk of ureteral injury, OR = 2.67; 95 % CI 1.26-5.65.

Conclusion: In this nationwide study laparoscopic surgery for rectal cancer with curative intent was associated with a significantly increased risk of iatrogenic ureteral injury compared to open surgery.

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